Medicine Lake Volcano is a large shield volcano in northeastern California about 30 mi (50 km) northeast of Mount Shasta. The volcano is located in a zone of east-west crustal extension east of the main axis of the Cascade Volcanic Arc and the Cascade Range. The 0.6 mi (1 km) thick shield is 22 mi (35 km) from east to west and 28 to 31 mi from north to south, and covers more than 770 sq mi (2,000 km2). The underlying rock has downwarped by 0.3 mi (0.5 km) under the center of the volcano. The volcano is primarily composed of basalt and basaltic andesite lava flows, and has a 4.3 by 7.5 mi caldera at the center.

The Cascade Volcanoes are a number of volcanoes in a volcanic arc in western North America, extending from southwestern British Columbia through Washington and Oregon to Northern California, a distance of well over 700 miles (1,100 km). The arc formed due to subduction along the Cascadia subduction zone. Although taking its name from the Cascade Range, this term is a geologic grouping rather than a geographic one, and the Cascade Volcanoes extend north into the Coast Mountains, past the Fraser River which is the northward limit of the Cascade Range proper.