Medicine Park is a town in Comanche County, Oklahoma, United States, situated in the Wichita Mountains near the entrance to the 60,000-acre (240 km2) Wichita Mountain Wildlife Refuge. Medicine Park has a long history as a vintage cobblestone resort town. Medicine Park is located near the city of Lawton and Fort Sill. It is an exurb, part of the Lawton Metropolitan Statistical Area. Many of the original structures are constructed of naturally formed cobblestones—these red granite cobblestones are unique to the Wichita Mountains. The population was 382 at the 2010 census.

Comanche County is a county located in the U.S. state of Oklahoma. As of the 2020 census, the population was 121,125, making it the fifth-most populous county in Oklahoma. Its county seat is Lawton. The county was created in 1901 as part of Oklahoma Territory. It was named for the Comanche tribal nation.