Medicine for Melancholy is a 2008 romantic drama film written and directed by Barry Jenkins in his feature directorial debut. The film stars Wyatt Cenac, Tracey Heggins, and Elizabeth Acker.

Barry Jenkins is an American filmmaker. After making his filmmaking debut with the short film My Josephine (2003), he directed his first feature film Medicine for Melancholy (2008) for which he received an Independent Spirit Award nomination for Best First Feature. He is also a member of The Chopstars collective as a creative collaborator.