The Medieval Inquisition was a series of Inquisitions from around 1184, including the Episcopal Inquisition (1184–1230s) and later the Papal Inquisition (1230s). The Medieval Inquisition was established in response to movements considered apostate or heretical to Roman Catholicism, in particular Catharism and Waldensians in Southern France and Northern Italy. These were the first movements of many inquisitions that would follow.

The Waldensians, also known as Waldenses, Vallenses, Valdesi, or Vaudois, are adherents of a church tradition that began as an ascetic movement within Western Christianity before the Reformation. Originally known as the Poor of Lyon in the late twelfth century, the movement spread to the Cottian Alps in what is today France and Italy. The founding of the Waldensians is attributed to Peter Waldo, a wealthy merchant who gave away his property around 1173, preaching apostolic poverty as the way to perfection.