The Mediterranean campaign of 1798 was a series of major naval operations surrounding a French expeditionary force sent to Egypt under Napoleon Bonaparte during the French Revolutionary Wars. The French Republic sought to capture Egypt as the first stage in an effort to threaten British India and support Tipu Sultan, and thus force Great Britain to make peace. Departing Toulon in May 1798 with over 40,000 troops and hundreds of ships, Bonaparte's fleet sailed southeastwards across the Mediterranean Sea. They were followed by a small British squadron under Rear-Admiral Sir Horatio Nelson, later reinforced to 13 ships of the line, whose pursuit was hampered by a lack of scouting frigates and reliable information. Bonaparte's first target was the island of Malta, which was under the government of the Knights of St. John and theoretically granted its owner control of the Central Mediterranean. Bonaparte's forces landed on the island and rapidly overwhelmed the defenders, securing the port city of Valletta before continuing to Egypt. When Nelson learned of the French capture of the island, he guessed the French target to be Egypt and sailed for Alexandria, but passed the French during the night of 22 June without discovering them and arrived off Egypt first.

Ferdinand von Hompesch zu Bolheim, O.S.I. was the 71st Grand Master of the Knights Hospitaller, formally the Order of St. John of Jerusalem, by then better known as the Knights of Malta. He was the first German elected to the office. It was under his rule that the Order lost the island of Malta to France, after ruling there since 1530. This effectively marked the end of their sovereignty over an independent state, dating from the time of the Crusades.