The Medora site (16WBR1) is an archaeological site that is a type site for the prehistoric Plaquemine culture period. The name for the culture is taken from the proximity of Medora to the town of Plaquemine, Louisiana. The site is in West Baton Rouge Parish, Louisiana, and was inhabited from approximately 1300 to 1600 CE. It consisted of two mounds separated by a plaza. In the winter of 1939–1940 excavation of this site was undertaken by the Louisiana State Archaeological Survey, a joint project of Louisiana State University and the Work Projects Administration. It was directed by James A. Ford, and George I. Quimby. The excavations of the site were instrumental in defining the characteristics of the Plaquemine period and culture.

The Plaquemine culture was an archaeological culture centered on the Lower Mississippi River valley. It had a deep history in the area stretching back through the earlier Coles Creek and Troyville cultures to the Marksville culture. The Natchez and related Taensa peoples were their historic period descendants. The type site for the culture is the Medora site in Louisiana; while other examples include the Anna, Emerald, Holly Bluff, and Winterville sites in Mississippi.