Medusa is a fictional character appearing in DC Comics publications and related media, commonly as a recurring adversary of the superhero Wonder Woman. Based upon the eponymous Greek mythological figure whose story was chronicled in Ovid's Metamorphoses, she is a snake-haired Gorgon with the ability to turn living creatures to stone with her gaze. Since her debut in 1964, Medusa's physical appearance has been presented variously as DC Comics' continuities have shifted and evolved. Though she has routinely been depicted with snakes for hair, she has sometimes been shown as bipedal and sometimes with a serpentine lower body. However across continuities, she has consistently been written with the ghostly ability to possess or influence other beings after her physical body has been killed, as well as an uncanny capacity for resurrection after death. Her characterization has been that of a dangerous immortal creature who is at turns both vengeful and sympathetic.

Wonder Woman is a superheroine created by the American psychologist and writer William Moulton Marston, and artist Harry G. Peter in 1941 for DC Comics. Marston's wife, Elizabeth, and their life partner, Olive Byrne, are credited as being his inspiration for the character's appearance.