Medzhybizh, formerly Mezhybozhe, is a rural settlement in Khmelnytskyi Oblast, western Ukraine. It is located in Khmelnytskyi Raion, 25 kilometres from Khmelnytskyi on the main highway between Khmelnytskyi and Vinnytsia at the confluence of the Southern Buh and Buzhok rivers. Medzhybizh was once a prominent town in the former Podolia Province. Its name is derived from "mezhbuzhye", which means "between the Buzhenka Rivers". It is known as the birthplace of the Jewish Hasidic mystical religious movement. Medzhybizh hosts the administration of Medzhybizh settlement hromada, one of the hromadas of Ukraine. Current population: 1,237 ; 1,731,.

Khmelnytskyi Oblast, also known as Khmelnychchyna, is an oblast (province) in western Ukraine covering portions of the historical regions of western Podolia and southern Volhynia. The administrative center of the oblast is the city of Khmelnytskyi.