Megacephalosaurus is an extinct genus of short-necked pliosaur that inhabited the Western Interior Seaway of North America about 94 to 93 million years ago during the Turonian stage of the Late Cretaceous, containing the single species M. eulerti. It is named after its large head, which is the largest of any plesiosaur in the continent and measures up to 1.75 meters (5.7 ft) in length. Megacephalosaurus was one of the largest marine reptiles of its time with an estimated length of 6–9 meters (20–30 ft). Its long snout and consistently sized teeth suggest that it preferred a diet of smaller-sized prey.

Pliosauroidea is an extinct clade of plesiosaurs, known from the earliest Jurassic to early Late Cretaceous. They are best known for the subclade Thalassophonea, which contained crocodile-like short-necked forms with large heads and massive toothed jaws, commonly known as pliosaurs. More primitive non-thalassophonean pliosauroids resembled plesiosaurs in possessing relatively long necks and smaller heads. They originally included only members of the family Pliosauridae, of the order Plesiosauria, but several other genera and families are now also included, the number and details of which vary according to the classification used.