The Mekong River Commission (MRC) is an "...inter-governmental organisation that works directly with the governments of Cambodia, Laos, Thailand, and Vietnam to jointly manage the shared water resources and the sustainable development of the Mekong River". Its mission is "To promote and coordinate sustainable management and development of water and related resources for the countries' mutual benefit and the people's well-being".

The Mekong or Mekong River is a trans-boundary river in East Asia and Southeast Asia. It is the world's twelfth-longest river and the third-longest in Asia with an estimated length of 4,909 km (3,050 mi) and a drainage area of 795,000 km2 (307,000 sq mi), discharging 475 km3 (114 cu mi) of water annually. From its headwaters in the Tibetan Plateau, the river runs through Southwest China, Myanmar, Laos, Thailand, Cambodia, and southern Vietnam. The extreme seasonal variations in flow and the presence of rapids and waterfalls in the Mekong make navigation difficult. Even so, the river is a major trade route between Tibet and Southeast Asia. The construction of hydroelectric dams along the Mekong in the 2000s through the 2020s has caused serious problems for the river's ecosystem, including the exacerbation of drought.