Mel Lopez Boulevard is a 6.2-kilometer (3.9 mi), six-to-ten lane divided highway in northern Manila, Philippines, connecting Bonifacio Drive in Port Area in the south with Radial Road 10 (R-10) in Navotas in the north. The highway is the main component of the R-10 network, which runs north of the Pasig River until Anda Circle, and is an extension of Bonifacio Drive, running north–south through the Manila North Port area serving the coastal districts of Tondo and Port Area, as well as San Nicolas and Intramuros.

Bonifacio Drive is a road running for approximately 1 kilometer (0.62 mi) in a north-south direction between Intramuros and Port Area in Manila, Philippines. The boulevard is also designated as Radial Road 1 (R-1) of Manila's arterial road network, National Route 120 (N120) of the Philippine highway network and an auxiliary route of Asian Highway 26 (AH26).