Melipilla is a Chilean commune and capital city of the province of the same name. It is part of the Santiago Metropolitan Region and is a significant satellite city of the Chilean capital.

Santiago Metropolitan Region is one of Chile's 16 first-order administrative divisions. It is the country's only landlocked administrative region and contains the nation's capital, Santiago. Most commercial and administrative centers are located in the region, including Chile's main international airport, Arturo Merino Benítez International Airport.