The Melkite Greek Catholic Church, or Melkite Byzantine Catholic Church, is an Eastern Catholic church in full communion with the Holy See as part of the worldwide Catholic Church. Its chief pastor is Patriarch Youssef Absi, headquartered at the Cathedral of Our Lady of the Dormition in Damascus, Syria. The Melkites, who are Byzantine Rite Catholics, trace their history to the early Christians of Antioch, formerly part of Syria and now in Turkey, of the 1st century AD, where Christianity was introduced by Saint Peter.

Antioch on the Orontes was a Hellenistic Greek city founded by Seleucus I Nicator in 300 BC. It was one of the greatest and most important Greek cities of the Hellenistic period. The city served as the capital of the Greek Seleucid Empire and later as regional capital to both the Roman and Byzantine Empire. During the Crusades, Antioch served as the capital of the Principality of Antioch, one of four Crusader states that were founded in the Levant. The modern city of Antakya, in Hatay Province of Turkey, was named after the ancient city, which lies in ruins on the Orontes River and did not overlap in habitation with the modern city.