The Mellon family is a wealthy and influential American family from Pittsburgh, Pennsylvania. The family includes Andrew Mellon, one of the longest serving U.S. Treasury Secretaries, along with famous members in the judicial, banking, financial, business, and political professions. Other notable figures include the prominent banker, R.B. Mellon, and his son R.K. Mellon, who provided funding and leadership for the first Pittsburgh Renaissance.

Andrew William Mellon, known also as A. W. Mellon, was an American banker, businessman, industrialist, philanthropist, art collector, and politician. From the wealthy Mellon family of Pittsburgh, Pennsylvania, he established a vast business empire before moving into politics. He served as United States Secretary of the Treasury from March 9, 1921, to February 12, 1932, presiding over the boom years of the 1920s and the Wall Street Crash of 1929. A conservative Republican, Mellon favored policies that reduced taxation and the national debt of the United States in the aftermath of World War I. Mellon also helped fund and manage Kennywood Park in West Mifflin, Pennsylvania.