Melrose is a mostly residential neighborhood in the southwestern section of the New York City borough of the Bronx. It adjoins the business and one-time theater area known as The Hub. Melrose is rectangular-shaped, being bordered by Saint Anns Avenue on the east, 149th Street on the south, Park Avenue on the west, and 163rd Street to the north. Melrose Avenue and Third Avenue are the primary thoroughfares through Melrose.

The Hub is a major commercial center for the South Bronx, New York. It is located where four roads converge: East 149th Street, and Willis, Melrose and Third Avenues. It is primarily located inside the neighborhood of Melrose but also lines the northern border of Mott Haven.