The Memphis–Clarksdale-Forrest City Combined Statistical Area, TN–MS–AR (CSA) is the commercial and cultural hub of the Mid-South or Ark-Miss-Tenn. The census-defined combined statistical area covers eleven counties in three states, Tennessee, Mississippi, and Arkansas. As of 2020 census, the Memphis metropolitan area had a population of 1,389,905 The Forrest City, Arkansas Micropolitan area was added to the Memphis area in 2012 to form the Memphis–Forrest City Combined Statistical area. In 2023 the Clarksdale, Mississippi Micropolitan area was also added to form the new Memphis-Clarksdale-Forrest City Combined Statistical Area which as of 2023 had a population of roughly 1.4 million people according to census estimates.

The Missouri Bootheel is a salient (protrusion) located in the southeasternmost part of the U.S. state of Missouri, extending south of 36°30′ north latitude, so called because its shape in relation to the rest of the state resembles the heel of a boot. Strictly speaking, it is composed of some or all of the counties of Dunklin, New Madrid, and Pemiscot. However, the term is locally used to refer to the entire southeastern lowlands of Missouri located within the Mississippi Embayment, which includes parts of Butler, Mississippi, Ripley, Scott, Stoddard and extreme southern portions of Cape Girardeau and Bollinger counties. The largest city in the region is Kennett.