Mendoza Province is Argentina's most important wine region, accounting for nearly two-thirds of the country's entire wine production. Located in the eastern foothills of the Andes, in the shadow of Aconcagua, vineyards are planted at some of the highest altitudes in the world, with the average site located 600–1,100 metres (2,000–3,600 ft) above sea level. The principal wine producing areas fall into two main departments-Maipú and Luján, which includes Argentina's first delineated appellation established in 1993 in Luján de Cuyo. The pink-skinned grapes of Criolla Grande and Cereza account for more than a quarter of all plantings but Malbec is the region's most important planting, followed closely by Cabernet Sauvignon, Tempranillo and Chardonnay. Mendoza is considered the heart of the winemaking industry in Argentina with the vast majority of large wineries located in the provincial capital of Mendoza.

Argentina is the fifth largest producer of wine in the world. Argentine wine, as with some aspects of Argentine cuisine, has its roots in Spain. During the Spanish colonization of the Americas, vine cuttings were brought to Santiago del Estero in 1557, and the cultivation of the grape and wine production stretched first to neighboring regions, and then to other parts of the country.