The W212 and S212 Mercedes-Benz E-Class series is the fourth-generation of the E-Class range of executive cars which was produced by Mercedes-Benz between 2009 and 2016 as the successor to the W211 E-Class. The body styles of the range are either 4-door sedan/saloon (W212) or a 5-door estate/wagon (S212). Coupé and convertible models of the E-Class of the same generation are W204 C-Class based and known as the C207 and A207, replacing the CLK-Class coupé and cabriolet. A high-performance E 63 AMG version of the W212 and S212 were available as well since 2009. In 2013, a facelift was introduced for the E-Class range, featuring significant styling changes, fuel economy improvements and updated safety features.

The Mercedes-Benz E-Class is a range of executive cars manufactured by German automaker Mercedes-Benz in various engine and body configurations. Produced since 1953, the E-Class falls midrange in the Mercedes line-up, and has been marketed worldwide across five generations.