The W213 Mercedes-Benz E-Class is the fifth-generation of the Mercedes-Benz E-Class. Sold from 2016, it is the successor to the W212/S212 E-Class models. The coupe/convertible models share the same platform as the sedan/wagon, in contrast to the previous generation. The high-performance Mercedes-AMG E 63 and E 63 S versions of the W213 have been available as well from 2016, and these are the only versions with V8 engines.

The W212 and S212 Mercedes-Benz E-Class series is the fourth-generation of the E-Class range of executive cars which was produced by Mercedes-Benz between 2009 and 2016 as the successor to the W211 E-Class. The body styles of the range are either 4-door sedan/saloon (W212) or a 5-door estate/wagon (S212). Coupé and convertible models of the E-Class of the same generation are W204 C-Class based and known as the C207 and A207, replacing the CLK-Class coupé and cabriolet. A high-performance E 63 AMG version of the W212 and S212 were available as well since 2009. In 2013, a facelift was introduced for the E-Class range, featuring significant styling changes, fuel economy improvements and updated safety features.