The Merchant Hotel, also known as the Merchants' Hotel, is a historic former hotel building in Portland, Oregon, United States. It is located at 121 N.W. Second Avenue in Old Town Chinatown. It is a contributing property in the Portland Skidmore/Old Town Historic District, which was listed on the U.S. National Register of Historic Places in 1975 and designated a National Historic Landmark District in 1977. It is one of the few remaining examples of Victorian Italianate, cast iron architecture on the West Coast. It occupies half of a city block, specifically along the south side of N.W. Davis Street from Second to Third Avenues.

William Sumio Naito was an American businessman, civic leader and philanthropist in Portland, Oregon, U.S. He was an enthusiastic advocate for investment in downtown Portland, both private and public, and is widely credited for helping to reverse a decline in the area in the 1970s through acquiring and renovating derelict or aging buildings and encouraging others to invest in downtown and the central city.