Mercy Hospital and Medical Center now called Insight Hospital and Medical Center Chicago is a 414-bed general medical and surgical Catholic teaching hospital in Chicago, Illinois. Established in 1852, the hospital was the first chartered hospital in Chicago. In 1859, Mercy Hospital became the first Catholic hospital to affiliate with a medical school—Lind Medical School—and the first to require a graded curriculum.

Prairie Avenue is a north–south street on the South Side of Chicago, which historically extended from 16th Street in the Near South Side to the city's southern limits and beyond. The street has a rich history from its origins as a major trail for horseback riders and carriages. During the last three decades of the 19th century, a six-block section of the street served as the residence of many of Chicago's elite families and an additional four-block section was also known for grand homes. The upper six-block section includes part of the historic Prairie Avenue District, which was declared a Chicago Landmark and added to the National Register of Historic Places.