Mesa de Ocaña is a comarca in Castilla-La Mancha, Spain, in the province of Toledo. Its capital and administrative center is Ocaña. The comarca is located in the northeast part of the province, and encompasses an area that includes several hundred meters of the Tajo River Valley.

In Spain, a comarca is either a traditional territorial division without any formal basis, or a group of municipalities, legally defined by an autonomous community for the purpose of providing common local government services. In English, a comarca is equivalent to a district, county, area or zone.