Mesick is a village in Wexford County in the U.S. state of Michigan. The population was 397 at the 2020 census. The majority of the village is located within Springville Township with a very small portion extending east into Antioch Township.

Wexford County is a county in the Northern Lower Peninsula of the U.S. state of Michigan. As of the 2020 United States census, the population was 33,673. The seat of Wexford County is Cadillac, which is also the county's largest city.