Messina is a harbour city and the capital of the Italian Metropolitan City of Messina. It is the third largest city on the island of Sicily, and the 13th largest city in Italy, with a population of more than 218,000 inhabitants in the city proper and about 650,000 in the Metropolitan City. It is located near the northeast corner of Sicily, at the Strait of Messina and it is an important access terminal to Calabria region, Villa San Giovanni, Reggio Calabria on the mainland. According to Eurostat the FUA of the metropolitan area of Messina has, in 2014, 277,584 inhabitants.

Reggio di Calabria, commonly and officially referred to as Reggio Calabria, or simply Reggio by its inhabitants, is the largest city in Calabria as well as the seat of the Regional Council of Calabria. It has an estimated population between 150,000 and 200,000 and is the twenty-first most populous city in Italy, after Modena and other Italian cities, and the 100th most populated city in Europe. Reggio Calabria is located near the center of the Mediterranean and is known for its climate, ethnic and cultural diversity. It is the third economic centre of mainland Southern Italy. About 560,000 people live in the metropolitan area, recognised in 2015 by Italy as a metropolitan city.