The Methodist Episcopal Church (MEC) was the oldest and largest Methodist denomination in the United States from its founding in 1784 until 1939. It was also the first religious denomination in the US to organize itself nationally. In 1939, the MEC reunited with two breakaway Methodist denominations to form the Methodist Church. In 1968, the Methodist Church merged with the Evangelical United Brethren Church to form the United Methodist Church.

Methodism, also called the Methodist movement, is a Protestant Christian tradition whose origins, doctrine and practice derive from the life and teachings of John Wesley. George Whitefield and John's brother Charles Wesley were also significant early leaders in the movement. They were named Methodists for "the methodical way in which they carried out their Christian faith". Methodism originated as a revival movement within Anglicanism originating out of the Church of England in the 18th century and became a separate denomination after Wesley's death. The movement spread throughout the British Empire, the United States and beyond because of vigorous missionary work, and today has about 80 million adherents worldwide.