Metlakatla is a census-designated place (CDP) on Annette Island in Prince of Wales-Hyder Census Area, Alaska, United States. At the 2010 census the population was 1,405; this had grown to 1,454 by the 2020 census.

Annette Island or Taak'w Aan (Tlingit) is an island in the Gravina Islands of the Alexander Archipelago of the Pacific Ocean on the southeastern coast of the U.S. state of Alaska. It is at 55°08′06″N 131°27′21″W. It is about 18 km (11 mi) long and about 18 km (11 mi) wide. The land area is 332.573 km2 (128.407 sq mi). Annette Island is located west across the Revillagigedo Channel from the Alaska mainland and south of Revillagigedo Island. The Island was named in 1879 by William Healey Dall, an American naturalist and explorer in Alaska, in honor of his wife Annette Whitney Dall.