The Metropolitan Borough of Knowsley is a metropolitan borough in Merseyside, North West England. It covers several towns and villages, including Kirkby, Prescot, Huyton, Whiston, Halewood, Cronton and Stockbridge Village; Kirkby, Huyton, and Prescot being the major commercial centres. It takes its name from the village of Knowsley, though its headquarters are in Huyton. It forms part of the wider Liverpool City Region.

Merseyside is a ceremonial and metropolitan county in North West England. It borders Lancashire to the north, Greater Manchester to the east, Cheshire to the south, the Welsh county of Flintshire across the Dee Estuary to the southwest, and the Irish Sea to the west. The largest settlement is the city of Liverpool.