The Metropolitan Center for High Technology, formerly S. S. Kresge World Headquarters, is an office building located at 2727 Second Avenue in Midtown Detroit, Michigan. It was listed on the National Register of Historic Places and designated a Michigan State Historic Site in 1979. The office building is now part of Wayne State University and used as a business incubator for startup companies.

Midtown Detroit is a commercial and residential district located along the east and west side of Woodward Avenue, north of Downtown Detroit, and south of the New Center area. The area includes several historic districts. In addition, it contains a residential area of some 14,550 people and covers 2.09 sq mi. The community area of neighborhoods is bounded by the Chrysler Freeway (I-75) on the east, the Lodge Freeway (M-10) on the west, the Edsel Ford Freeway (I-94) on the north, and the Fisher Freeway (I-75) on the south.