Mexican Spitfire refers to a series of eight comedy films released by RKO Pictures between 1940 and 1943 starring Lupe Vélez and Leon Errol. The movies featured the character of Carmelita Fuentes, a sympathetic but temperamental Mexican singer who leaves her career and native country to meet and marry Dennis Lindsay, an elegant and handsome American advertising executive.

María Guadalupe Villalobos Vélez, known professionally as Lupe Vélez, was a Mexican actress, singer, and dancer during the Golden Age of Hollywood cinema.