Compañía Mexicana de Aviación, S.A. de C.V. was Mexico's oldest airline and one of the oldest continuously single-branded airlines, inaugurated in 1921. It was Mexico's biggest airline and flagship airline before ceasing operations on August 28, 2010, leaving competitor Aeromexico as a de facto monopoly.

Volaris is a Mexican low-cost airline based in Santa Fe, Álvaro Obregón, Mexico City with its operating bases in Cancún, Culiacán, Guadalajara, León/Del Bajío, Mexicali, Mexico City, Monterrey, and Tijuana. It is Mexico's largest airline by transported passengers and serves domestic and international destinations within the Americas. It is the leading airline in the Mexican domestic airline market with a market share of 42%.