Ties between Mexico and Spain date back to the Spanish conquest of Mexico in 1519 and subsequent Spanish colonialism in the country which lasted until the end of the Mexican War of Independence in 1821. Formal diplomatic relations between both nations commenced in 1836 and were severed with the aftermath of the Spanish Civil War in 1939. Diplomatic relations were re-established in 1977 and have continued unabated since.

Spanish Mexicans are citizens or residents of Mexico who identify as Spanish as a result of nationality or recent ancestry. Spanish immigration to Mexico began in the early 1500s and spans to the present day. The vast majority of Mexicans have at least partial Spanish ancestry; the Northern regions of Mexico have a higher prevalence of Spanish heritage. There are three recognized large-scale Spanish immigration waves to the territory which is now Mexico: the first arrived during the colonial period, the second during the Porfiriato and the third after the Spanish Civil War.