The Michigan Central Railroad was originally chartered in 1832 to establish rail service between Detroit, Michigan, and St. Joseph, Michigan. The railroad later operated in the states of Michigan, Indiana, and Illinois in the United States and the province of Ontario in Canada. After about 1867 the railroad was controlled by the New York Central Railroad, which later became part of Penn Central and then Conrail. After the 1998 Conrail breakup, Norfolk Southern Railway now owns much of the former Michigan Central trackage.

The New York Central Railroad was a railroad primarily operating in the Great Lakes and Mid-Atlantic regions of the United States. The railroad primarily connected greater New York and Boston in the east with Chicago and St. Louis in the Midwest, along with the intermediate cities of Albany, Buffalo, Cleveland, Cincinnati, Detroit, Rochester and Syracuse. New York Central was headquartered in New York City's New York Central Building, adjacent to its largest station, Grand Central Terminal.