Microsoft Office, or Office, is a family of client software, server software, services developed by Microsoft. It was first announced by Bill Gates on August 1988, at COMDEX in Las Vegas. A marketing term for an office suite, the first version of Office contained Microsoft Word, Microsoft Excel, Microsoft PowerPoint. Over the years, Office applications have grown closer with shared features such as a common spell checker, OLE data integration and Visual Basic for Applications scripting language. Microsoft positions Office as a development platform for line-of-business software under the Office Business Applications brand. On July 10, 2012, Softpedia reported. Office is produced in several versions targeted towards different end-users and computing environments; the original, most used version, is the desktop version, available for PCs running the Windows and macOS operating systems. Office in a browser known as Office Online, is a version of the software that runs within a web browser, while Microsoft maintains Office apps for Android and iOS.
Since Office 2013, Microsoft has promoted Office 365 as the primary means of obtaining Microsoft Office: it allows use of the software and other services on a subscription business model, users receive free feature updates to the software for the lifetime of the subscription, including new features and cloud computing integration that are not included in the "on-premises" releases of Office sold under conventional license terms. In 2017, revenue from Office 365 overtook conventional license sales; the current on-premises, desktop version of Office is Office 2019, released on September 24, 2018. Unless stated otherwise, desktop applications are available for Windows and macOS. Microsoft Word: a word processor included in Microsoft Office and some editions of the now-discontinued Microsoft Works; the first version of Word, released in the autumn of 1983, was for the MS-DOS operating system and introduced the computer mouse to more users. Word 1.0 could be purchased with a bundled mouse. Following the precedents of LisaWrite and MacWrite, Word for Macintosh attempted to add closer WYSIWYG features into its package.
Word for Mac was released in 1985. Word for Mac was the first graphical version of Microsoft Word, it implemented the proprietary.doc format as its primary format. Word 2007, deprecated this format in favor of Office Open XML, standardized by Ecma International as an open format. Support for Portable Document Format and OpenDocument was first introduced in Word for Windows with Service Pack 2 for Word 2007. Microsoft Excel: a spreadsheet editor that competed with the dominant Lotus 1-2-3 and outsold it. Microsoft released the first version of Excel for the Mac OS in 1985 and the first Windows version in November 1987. Microsoft PowerPoint: a presentation program used to create slideshows composed of text and other objects, which can be displayed on-screen and shown by the presenter or printed out on transparencies or slides. Microsoft Outlook: a personal information manager that replaces Windows Messaging, Microsoft Mail, Schedule+ starting in Office 97. On the Mac OS, Microsoft offered several versions of Outlook in the late 1990s, but only for use with Microsoft Exchange Server.
In Office 2001, it introduced an alternative application with a different feature set called Microsoft Entourage. It reintroduced Outlook in Office 2011. Microsoft OneNote: a notetaking program that gathers handwritten or typed notes, screen clippings and audio commentaries. Notes can be shared with other OneNote users over a network. OneNote was introduced as a standalone app, not included in any of Microsoft Office 2003 editions. However, OneNote became a core component of Microsoft Office. OneNote is available as a web app on Office Online, a freemium Windows desktop app, a mobile app for Windows Phone, iOS, Symbian, a Metro-style app for Windows 8 or later. Microsoft Publisher: a desktop publishing app for Windows used for designing brochures, calendars, greeting cards, business cards, web site, postcards. Microsoft Access: a database management system for Windows that combines the relational Microsoft Jet Database Engine with a graphical user interface and software development tools. Microsoft Access stores data in its own format based on the Access Jet Database Engine.
It can import or link directly to data stored in other applications and databases. Skype for Business: an integrated communications client for conferences and meetings in real time, it is the only Microsoft Office desktop app, neither useful without a proper network infrastructure nor has the "Microsoft" prefix in its name. Microsoft Project: a project management app for Windows to keep track of events and to create network charts and Gantt charts, not bundled in any Office suite. Microsoft Teams: a platform that combines workplace chat, meetings and attachments. Microsoft announced that Teams would replace Skype for Business. Microsoft Visio: a diagram and flowcharting app for Windows not bundled in any Office suite. Office Lens: An image scanner optimized for mobile devices, it captures the document (e.g. business card
Kinesin family member 3B is a protein that in humans is encoded by the KIF3B gene. KIF3B is an N-type protein that complexes with two other kinesin proteins to form two-headed anterograde motors. First, KIF3B forms a heterodimer with KIF3A (kinesin family member 3A. KAP3 binds to the tail domain to form a heterotrimeric motor; this motor has a plus end-directed microtubule sliding activity that exhibits a velocity of ∼0.3 μm/s a. There are 14 kinesin protein families and KIF3B is part of the Kinesin-2 family, of kinesins that can all form heterotrimeric complexes. Expression of the three motor subunits is ubiquitous; the KIG3A/3B/KAP3 motors can transport 90 to 160 nm in diameter organelles. Thjere are many orthologous KIF3B genes that are expressed in Drosophila, the sea urchin, Bos taurus, Canis familiaris, Equus caballus, Felis catus, Macaca mulatta, Mus musculus, Pan troglodytes, Rattus norvegicus; the heterotrimeric KIF3B/KIF3A/KAP3 motor machinery functions in the intracellular transport of multiple different molecules such as β-catenin and MT1-MMP.
KIF3B activity has been implicated with various cellular processes such as intracellular movement of organelles, intra-flagellar transport, chromosome movement during mitosis and meiosis, cellular interaction with the extracellular matrix. KIF3B regulates the interaction of cancer cells with the extracellular matrix, in particular the transport of MT1-MMP to the cancer cell front is essential for collagen fiber matrix realignment and degradation. KIF3B has been shown to interact with the SMC3 subunit of the cohesin complex and with RAB4A. Model organisms have been used in the study of KIF3B function. A conditional knockout mouse line called Kif3btm1bWtsi was generated at the Wellcome Trust Sanger Institute. Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion. Additional screens performed: - In-depth immunological phenotyping
Akuto is a 1965 Japanese film directed by Kaneto Shindo starring Kyōko Kishida. It is based on a story by Jun'ichirō Tanizaki. A bad man wants to sleep with a woman, he spies on her with the help of Jiju. The woman's husband Rokuro decides to leave the court, he tells his wife to stay behind. The bad guy intends to sleep with the woman but she goes with her husband. Jiju leaves with them; the bad man orders his soldiers to follow them, kill everyone except the woman. The bad man's soldiers catch up with them. One by one each of them combats the soldiers and dies, until only Rokuro is left, he fights bravely but is overwhelmed and dies. A servant of Rokuro kills the wife. Jiju brings the head of the woman back to the court of the bad man, she starts laughing. The severed head smiles. Akuto on IMDb Akuto at the Japanese Movie Database