The Midcontinent Rift System (MRS) or Keweenawan Rift is a 2,000 km (1,200 mi) long geological rift in the center of the North American continent and south-central part of the North American plate. It formed when the continent's core, the North American craton, began to split apart during the Mesoproterozoic era of the Precambrian, about 1.1 billion years ago. The rift failed, leaving behind thick layers of igneous rock that are exposed in its northern reaches, but buried beneath later sedimentary formations along most of its western and eastern arms. Those arms meet at Lake Superior, which is contained within the rift valley. The lake's north shore in Ontario and Minnesota defines the northern arc of the rift. From the lake, the rift's eastern arm trends south to central lower Michigan, and possibly into Indiana, Ohio, Kentucky, Tennessee, and Alabama. The western arm runs from Lake Superior southwest through portions of Wisconsin, Minnesota, Iowa, and Nebraska to northeastern Kansas, and possibly into Oklahoma.

Lake Nipigon is part of the Great Lakes drainage basin. It is the largest lake entirely within the boundaries of the Canadian province of Ontario.