The Middle Fork Coquille River is a tributary, about 40 miles (64 km) long, of the South Fork Coquille River in the U.S. state of Oregon. It begins near Camas Mountain in Douglas County in the Southern Oregon Coast Range. It flows generally south, bypassing the community of Camas Valley while passing through the valley of the same name, then curves west and north to Remote in Coos County. The Middle Fork then flows generally west, passes by the small community of Bridge, and meets the South Fork near Myrtle Point. The confluence with the South Fork is 41 miles (66 km) by water to where the main stem of the Coquille River enters the Pacific Ocean at Bandon.

The South Fork Coquille River is the longest tributary of the Coquille River in coastal Oregon in the United States. From its headwaters in the Southern Oregon Coast Range, the river flows northwest to join the North Fork Coquille River at Myrtle Point, forming the main stem Coquille. The South Fork is about 63 miles (101 km) long, and its watershed drains roughly 288 square miles (750 km2) of rural Coos County.