The region of Middle Hesse is one of three planning regions in the German state of Hesse, alongside North and South Hesse. Its territory is identical with that of the administrative province of Gießen and covers the counties of Limburg-Weilburg, Lahn-Dill-Kreis, Gießen, Marburg-Biedenkopf and Vogelsbergkreis. The Middle Hesse Regional Assembly, which decides on the regional plan, currently consists of 31 members chosen by the five counties and the three towns with special status: Gießen, Marburg and Wetzlar. The regional assembly has tasked the governing president (Regierungspräsident) with delivering regional management. The Mid-Hesse Regional Management Association was founded on 22 January 2003.

The Gladenbach Uplands, named after their central town of Gladenbach, is a range of hills up to 609 m high in the Rhine Massif in Germany, on the junction of the Rothaar Mountains, Westerwald (southwest), (Eastern) Hintertaunus and West Hesse Highlands in the east. It lies in Central Hesse within the districts of Marburg-Biedenkopf, Lahn-Dill and Gießen within the so-called Lahn-Dill-(Dietzhölze-) loop. Small parts of the Upper Lahn Valley in the northwest belong, together with the town of Bad Laasphe, also to the district of Siegen-Wittgenstein, North Rhine-Westphalia.