The Middlesex Turnpike was an early turnpike between Cambridge and Tyngsborough, Massachusetts and the New Hampshire border, where it connected with the Amherst Turnpike and thence Nashua and Claremont, New Hampshire.

Cambridge is a city in Middlesex County, Massachusetts, United States. It is a suburb in the Greater Boston metropolitan area, located directly across the Charles River from Boston. The city's population as of the 2020 U.S. census was 118,403, making it the most populous city in the county, the fourth-largest in Massachusetts, behind Boston, Worcester, and Springfield, and ninth-most populous in New England. The city was named in honor of the University of Cambridge in Cambridge, England, which was an important center of the Puritan theology that was embraced by the town's founders.