Middleton or Middleton-by-Wirksworth is an upland village and civil parish lying approximately one mile NNW of Wirksworth, Derbyshire, England. Middleton was, in 1086, a berewick of the town and manor of Wirksworth. Middleton was formerly known for its lead mines and high quality limestone quarries, including the underground quarry site at Middleton Mine. The Middleton Mine networks underground for approximately 25 miles (40 km) with tunnels on three different levels running under Middleton Moor to the Hopton Wood quarry works at the other side of the hill below Ryder Point Works’. Part of the tunnel collapsed in the 1970s leaving a noticeable depression in the ground above on the eastern side of Middleton Moor. The population of the parish as taken at the 2011 Census was 775.

Wirksworth is a market, and former quarry town in the Derbyshire Dales district of Derbyshire, England. Its population of 4,904 in the 2021 census was estimated at 5,220 in 2023. Wirksworth contains the source of the River Ecclesbourne. The town was granted a market charter by Edward I in 1306 and still holds a market on Tuesdays in the Memorial Gardens. The parish church of St Mary's is thought to date from 653. The town developed as a centre for lead mining and stone quarrying. Many lead mines were owned by the Gell family of nearby Hopton Hall.