Middleton Place is a plantation in Dorchester County, along the banks of the Ashley River west of the Ashley and about 15 miles (24 km) northwest of downtown Charleston, in the U.S. state of South Carolina. Built in several phases during the 18th and 19th centuries, the plantation was the primary residence of several generations of the Middleton family, many of whom played prominent roles in the colonial and antebellum history of South Carolina. The plantation, now a National Historic Landmark District, is used as a museum, and is home to the oldest landscaped gardens in the United States.

Dorchester County is a county located in the U.S. state of South Carolina. As of the 2020 census, the population was 161,540. Its county seat is St. George.