Middletown station is an Amtrak train station on the Keystone Corridor in Middletown, Dauphin County in the U.S. state of Pennsylvania. The station is served by Amtrak's Keystone Service between New York City and Harrisburg. The former low-level station was built in 1990, but a relocated station with a high-level platform opened on January 10, 2022.

The Keystone Corridor is a 349-mile (562 km) railroad corridor between Philadelphia and Pittsburgh, Pennsylvania, that consists of two rail lines: Amtrak and SEPTA's Philadelphia-to-Harrisburg main line, which hosts SEPTA's Paoli/Thorndale Line commuter rail service, and Amtrak's Keystone Service and Pennsylvanian inter-city trains; and the Norfolk Southern Pittsburgh Line. The corridor was originally the Main Line of the Pennsylvania Railroad.