The Midlands region of South Carolina is the middle area of the state. The region's main center is Columbia, the state's capital. The Midlands is so named because it is halfway point between the Upstate and the Lowcountry. The main area code is 803.

Columbia is the capital city of the U.S. state of South Carolina. With a population of 136,632 at the 2020 census, it is the second-most populous city in South Carolina. The city serves as the county seat of Richland County, and a portion of the city extends into neighboring Lexington County. It is the center of the Columbia, SC Metropolitan Statistical Area, which had an estimated population of 858,302 in 2023, and is the 70th-most populous metropolitan statistical area in the United States. The name Columbia is a poetic term used for the United States, derived from the name of Christopher Columbus, who explored for the Spanish Crown. Columbia is often abbreviated as Cola, leading to its nickname as "Soda City".