C-C chemokine receptor type 10 is a protein that in humans is encoded by the CCR10 gene. Chemokines are a group of small basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines play fundamental roles in the development and function of the immune system, they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC, based on the arrangement of the first 2 of the 4 conserved cysteine residues. CCR10 is a chemokine receptor, its ligands are CCL27 and CCL28. This receptor is expressed by melanocytes, plasma cells and skin-homing T cells. B16 melanoma cell transduction of CCR10 increases the development of lymph node metastasis in mice after inoculation in the skin, suggesting a role for the receptor in directing metastasis. CCR10-CCL27 interactions are involved in T cell-mediated skin inflammation.
Human CCR10 genome location and CCR10 gene details page in the UCSC Genome Browser. "Chemokine Receptors: CCR10". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology; this article incorporates text from the United States National Library of Medicine, in the public domain
Alger County is a county in the Upper Peninsula of the U. S. state of Michigan. As of the 2010 census, the population was 9,601, its county seat is Munising. The Pictured Rocks National Lakeshore is located within the county. Alger County was detached from Schoolcraft County, set off and organized in 1885; the county was named for lumber baron Russell Alexander Alger, elected as a Michigan Governor, US Senator, appointed as US Secretary of War during the William McKinley Presidential administration. See List of Michigan county name etymologies, List of Michigan counties, List of abolished U. S. counties. According to the U. S. Census Bureau, the county has a total area of 5,048 square miles, of which 915 square miles is land and 4,133 square miles is water, it is the second-largest county in Michigan by total area because of Lake Superior on the north side of the county. Luce County – east Schoolcraft County – southeast Delta County – south Marquette County – west Thunder Bay District, Ontario – north Grand Island National Recreation Area Hiawatha National Forest Pictured Rocks National Lakeshore The 2010 United States Census indicates Alger County had a population of 9,601.
This decrease of 261 people from the 2000 United States Census represents a 2.6% population decrease. In 2010 there were 2,479 families residing in the county; the population density was 11 inhabitants per square mile. There were 6,554 housing units at an average density of 7 per square mile; the racial makeup of the county was 86.3% White, 6.4% Black or African American, 4.1% Native American, 0.3% Asian, 0.1% of some other race and 2.7% of two or more races. 1.2 % were Latino. Regarding specific ethnicities, 15.7% of the population was of German heritage, 13.5% Finnish, 12.6% French, French Canadian or Cajun, 9.3% English, 7.3% Polish, 6.9% Irish and 5.3% American ancestry. There were 3,898 households out of which 20.1% had children under the age of 18 living with them, 52.2% were married couples living together, 7.1% had a female householder with no husband present, 36.4% were non-families. 31.6% of all households were made up of individuals and 15.2% had someone living alone, 65 years of age or older.
The average household size was 2.2 and the average family size was 2.74. In the county, the population was spread out with 17.1% under the age of 18, 6.6% from 18 to 24, 22.8% from 25 to 44, 32.8% from 45 to 64, 20.7% who were 65 years of age or older. The median age was 47.3 years. The population was 45.6 % female. The median income for a household in the county was $38,231, the median income for a family was $46,154; the per capita income for the county was $19,858. About 9.3% of people in families and 14.0% of the population were below the poverty line, including 19.3% of those under age 18 and 8.2% of those age 65 or over. The county government operates the jail, maintains rural roads, operates local courts, records deeds and vital records, administers public health regulations, participates with the state in the provision of welfare and other social services; the county board of commissioners controls the budget and has limited authority to make laws or ordinances. In Michigan, most local government functions — police and fire and zoning, tax assessment, street maintenance, etc. — are the responsibility of individual cities and townships.
Munising Chatham Alger County contains two small portions of the Sault Tribe of Chippewa Indians tribal community, headquartered in Sault Ste. Marie in Chippewa County. One portion is in the northeastern corner of Au Train Township, another larger portion is about two miles south of Munising in Munising Township. Alger County was reliably Republican from the beginning through 1928. Since it has voted for the Democratic nominee 65% of the time. List of Michigan State Historic Sites in Alger County, Michigan National Register of Historic Places listings in Alger County, Michigan Alger County Online Greater Munising Bay Partnership for Commerce Development & Alger County Chamber *County Profile, Sam M Cohodas Regional Economist National Association of Counties - Alger County, MI Alger County Sheriff's Office US Coast Guard Auxiliary Flotilla 26-12 "Bibliography on Alger County". Clarke Historical Library, Central Michigan University. Retrieved July 2, 2013
Kjetil Øvrelid Strand is a Norwegian handball player. Strand played for Bjerringbro Silkeborg in Denmark before the 2006 European Championship. Afterwards he signed a contract with Aab Håndbold. On February 2, 2006, he scored 19 goals, a Norwegian record, in a Main Group Stage game against Iceland in the European Championship. Strand holds the record for number of goals scored in a single season in the Norwegian league: 281, he set the record while playing for Stavanger Håndball in 2002/2003 season. In 2003 he was awarded Player of the year in Norwegian handball. "Statistics for Strand, Kjetil Øvrelid". Norwegian Handball Association. Retrieved 2008-01-12
The Way of the World is an album by American jazz/blues singer Mose Allison, released in 2010 on ANTI-. It was his first studio album since 1997's Gewgaws, he decided to record the album after producer Joe Henry approached him in 2008 and persuaded him to come out of retirement. According to Metacritic, The Way of the World has a score of 78 out of 100, indicating that it has received "generally favorable reviews" from critics. All compositions by Mose Allison except as indicated. "My Brain" - 2:59 "I Know You Didn't Mean It" - 3:28 "Everybody Thinks You're an Angel" - 2:58 "Let It Come Down" - 2:31 "Modest Proposal" - 2:29 "Crush" - 2:55 "Some Right, Some Wrong" - 2:487 "The Way of the World" - 2:50 "Ask Me Nice" - 3:19 "Once in a While" - 3:32 "I'm Alright" - 3:11 "This New Situation" - 2:08 Mose Allison - piano, vocals Amy Allison - vocals on 12 Jay Bellerose - drums, percussion Greg Leisz - acoustic guitar, electric guitar and mandola David Piltch - upright bass Walter Smith III - tenor saxophone Anthony Wilson - electric guitar
An observation tower is a structure used to view events from a long distance and to create a full 360 degree range of vision to conduct the long distance observations. They are at least 20 metres tall and made from stone and wood. Many modern towers are used as TV towers, restaurants, or churches; the towers first appeared in the ancient world, as long ago as the Babylonian Empire. Observation towers that are used as guard posts or observation posts over an extended period to overlook an area are called watchtowers instead. Observation towers are an visible sight on the countryside, as they must rise over trees and other obstacles to ensure clear vision. Older control rooms have been likened to medieval chambers; the heavy use of stone and wood in their construction helps to create this illusion. Modern towers have observation decks or terraces with restaurants or on the roof of mountain stations of an aerial ropeway. Observation towers are used as location of radio services within the UHF/VHF range.
In some cases this usage of the tower is at least as important as its use as an observation tower. Such towers are called TV towers or telecommunication towers. Many towers are equipped with a tower restaurant and allow visitors access via elevators. Common is the usage of water towers as observation towers; as in the case of TV towers the visitor will reach the observation deck by elevator, at a lower height above ground The typical height of the observation deck of water towers is 20 metres up to 50 metres, while the typical height of the platform of TV towers is from 80 metres up to 200 metres. Some church towers may have observation decks, albeit without an elevator. Many other buildings may have towers. In particular prior to World War I rambler associations, some municipalities, built observation towers on numerous summits; these towers were built of stone, however sometimes wood or iron was used. At nearly all these towers access to the observation deck at a height of between 5 and 40 metres, is only possible by way of stairs.
Most of these towers are used only for tourism, however some of these towers might be used, at times of high forest fire risk, as fire observation posts or in times of war as military observation posts with anti-aircraft positions placed beside it. Further uses were not intended at most of these buildings, although some of these towers today now carry antennas for police/fire engine radios, portable radio or low power FM- and TV-transmitters. Older observation towers have a flag pole at its top; some of these towers are permanently accessible, either free or with the payment of an admission fee. Others are accessible only at certain times, in most cases only with the payment of an admission fee. At these towers the platform is open, with some having a restaurant in the basement. There are towers with a much more extensive use; the observation tower on Rossberg mountains in Reutlingen contains a hotel within its structure. Although most of these towers were built before World War I, such structures are still being built, in particular as attractions at horticultural shows.
Modern observation towers are in most cases no longer built of brick, but concrete and wood are used as the preferred building materials. Permanent observation towers are sometimes found in amusement parks, however in parks where each attraction is not separately paid for, panorama rides are preferred. Watch towers are observation towers. Speaking, control towers fall into this category, although surveillance from these structures is done in a non-optical way using Radar. Watch towers have a closed pulpit to protect the observer against bad weather. Watch towers do not have an elevator as a rule, since these buildings are not higher than 20 metres. Active watch towers are not as a rule accessible to the public, since they serve for the monitoring of sensitive ranges; however watch towers can be quite ordered for forest fire monitoring a platform accessible for the public or be used during times without forest fire risk as observation towers. Shut down watch towers can however be converted to observation towers.
Some radio towers were so built that they can be used apart from their function as transmitting tower as observation tower. A condition for this is a sufficiently stable construction, which permits a permanent safe visitor entrance without interruption of the transmission services; this is the case for towers for radio services in the UHF/VHF-range the case, not however for most types of radio towers for long and medium wave, why a use of these structures as observation tower is impossible in most cases. That the use of a tower as radio tower for medium wave and observation tower not well fits, showed up in Radio Tower Berlin, which carried together with an 80 metres high mast a t-antenna for medium wave and stands on insulators; however one notices at the first experimental transmissions that at the tower voltages would arise, which would have unpleasant consequences for visitors and so the tower was grounded by the elevator shaft. However this shifted direction of main beam of transmitter away from actual supply area, the city of Berlin.
As before World War II nearly whole radio traffic took place in the long -, medium and shortwave range, first after World War II with introduction of radio services in UHF/VHF-range required towers only acting as antenna carriers, radio towers with observation decks built. For this the closed rei