Midtown Plaza is a city district in downtown Rochester, New York. The site was originally occupied by an indoor shopping mall designed by Victor Gruen and opened in 1962. Although it was primarily promoted as a retail space, Gruen's vision was for the plaza to function as an all-purpose community space to revitalize the downtown area. The original mall was closed in 2008 after a decline in retail activity and partially demolished. Since 2010 the site has been redeveloped with new buildings and an open lot known as Parcel 5.

Downtown Rochester is the economic center of Rochester, New York, and the largest in Upstate New York, employing more than 50,000 people, and housing more than 6,000.