The Milan–Bologna railway is the northern part of the traditional main north–south trunk line of the Italian railway network. It closely follows the ancient Roman Road, the Via Aemilia. The line was opened between 1859 and 1861 as a single-line railway, and was doubled between 1866 and 1894. It was electrified at 3,000 volts DC in 1938. High-speed trains on the route have used the parallel Milan–Bologna high-speed line since 13 December 2008.

The Milan–Bologna high-speed railway is a railway line that links the cities of Milan and Bologna, part of the Italian high-speed rail network. It runs parallel to the historical north–south railway between Milan and Bologna, which itself follows the ancient Roman Road, the Via Aemilia. The new railway follows the Autostrada A1 closely for much of its length. The new line allows faster traffic to run separated and increase the overall railway capacity between the two cities.