Milan Kundera is a Czech writer who went into exile in France in 1975, becoming a naturalised French citizen in 1981. Kundera’s Czech citizenship was revoked in 1979 and was not restored until 2019, he "sees himself as a French writer and insists his work should be studied as French literature and classified as such in book stores". Kundera's best-known work is The Unbearable Lightness of Being. Prior to the Velvet Revolution of 1989 the socialist régime in Czechoslovakia banned his books, he lives incognito and speaks to the media. A perpetual contender for the Nobel Prize in Literature, he is believed to have been nominated on several occasions. Kundera was born in 1929 at Purkyňova 6 in Královo Pole, a quarter of Brno, Czechoslovakia, to a middle-class family, his father, Ludvík Kundera, was an important Czech musicologist and pianist who served as the head of the Janáček Music Academy in Brno from 1948 to 1961. His mother was Milada Kunderová. Milan learned to play the piano from his father.
Musicological influences and references can be found throughout his work. Kundera is a cousin of translator Ludvík Kundera, he belonged to the generation of young Czechs who had had little or no experience of the pre-war democratic Czechoslovak Republic. Their ideology was influenced by the experiences of World War II and the German occupation. Still in his teens, he joined the Communist Party of Czechoslovakia which seized power in 1948, he completed his secondary school studies in Brno at Gymnázium třída Kapitána Jaroše in 1948. He studied literature and aesthetics at the Faculty of Arts at Charles University in Prague. After two terms, he transferred to the Film Faculty of the Academy of Performing Arts in Prague where he first attended lectures in film direction and script writing. In 1950, his studies were interrupted by political interferences, he and writer Jan Trefulka were expelled from the party for "anti-party activities." Trefulka described the incident in his novella Pršelo jim štěstí.
Kundera used the incident as an inspiration for the main theme of his novel Žert. After Kundera graduated in 1952, the Film Faculty appointed him a lecturer in world literature. In 1956 Milan Kundera was readmitted into the Party, he was expelled for the second time in 1970. Kundera, along with other reform communist writers such as Pavel Kohout, was involved in the 1968 Prague Spring; this brief period of reformist activities was crushed by the Soviet invasion of Czechoslovakia in August 1968. Kundera remained committed to reforming Czechoslovak communism, argued vehemently in print with fellow Czech writer Václav Havel, saying that everyone should remain calm and that "nobody is being locked up for his opinions yet," and "the significance of the Prague Autumn may be greater than that of the Prague Spring." However, Kundera relinquished his reformist dreams and moved to France in 1975. He taught for a few years in the University of Rennes, he was stripped of Czechoslovak citizenship in 1979. He maintains contact with Czech and Slovak friends in his homeland, but returns and always does so incognito.
Although his early poetic works are staunchly pro-communist, his novels escape ideological classification. Kundera has insisted on being considered a novelist, rather than a political or dissident writer. Political commentary has all but disappeared from his novels except in relation to broader philosophical themes. Kundera's style of fiction, interlaced with philosophical digression, is inspired by the novels of Robert Musil and the philosophy of Nietzsche, is used by authors Alain de Botton and Adam Thirlwell. Kundera takes his inspiration, as he notes enough, not only from the Renaissance authors Giovanni Boccaccio and Rabelais, but from Laurence Sterne, Henry Fielding, Denis Diderot, Robert Musil, Witold Gombrowicz, Hermann Broch, Franz Kafka, Martin Heidegger, most Miguel de Cervantes, to whose legacy he considers himself most committed, he wrote in Czech. From 1993 onwards, he has written his novels in French. Between 1985 and 1987 he undertook the revision of the French translations of his earlier works.
As a result, all of his books exist in French with the authority of the original. His books have been translated into many languages. In his first novel, The Joke, he gave a satirical account of the nature of totalitarianism in the Communist era. Kundera was quick to criticize the Soviet invasion in 1968; this led to his works being banned there. Kundera's second novel was first published in French as La vie est ailleurs in 1973 and in Czech as Život je jinde in 1979. Set in Czechoslovakia before and after the Second World War, Life Is Elsewhere is a satirical portrait of the fictional poet Jaromil, a young and naive idealist who becomes involved in political scandals. In 1975, Kundera moved to France. There he published The Book of Laughter and Forgetting which told of Czechoslovak citizens opposing the communist regime in various ways. An unusual mixture of novel, short story collection and author's musings, the book set the tone for his works in exile. Critics have noted the irony that the country that Kundera seemed to be writing about when he talked about Czechoslovakia in the book, "is, thanks to the latest political redefinitions, no longer there", the
Manuel Abaunza is a retired Nicaraguan-American soccer inside right who played one season in the National Professional Soccer League. In 1960, the younger brother of Bayardo Abaunza, played for Vizcoya in Costa Rica, he moved to Los Angeles in 1961 where he joined the Los Angeles Kickers, an amateur team in the Greater Los Angeles League. In 1964, the Kickers won the 1964 National Challenge Cup over the Philadelphia Ukrainians. Abaunza scored in a 2-2 tie; the Kickers won the return leg 2-0 to take the title. In 1965, he moved to Orange County Soccer Club of the Continental League. In 1966, Orange County lost in the final of the 1966 National Challenge Cup. On January 29, 1967, Abaunza signed with the Los Angeles Toros of the National Professional Soccer League; the Toros folded at the end of the season and Abaunza moved to the Los Angeles Armenians in 1968 and Los Angeles Saprissa, a team composed entirely of Costa Rican players. In September 1969, he moved to San Pedro Olympia. Although he was called into the United States men's national soccer team in the 1960s, he never played for the team in a full international.
James Mullen was an English international footballer, who played as an outside left. Mullen spent his whole career at Wolverhampton Wanderers where he won three league championships and the FA Cup, he represented the English national team at both the 1950 and 1954 World Cup. Mullen joined the Midlanders in June 1937, turned professional on his 17th birthday, remained with the club until his retirement in May 1960, his league debut came in February 1939, in a 4–1 win over Leeds United. He made 488 appearances in total, scoring 112 goals, helping the club win their only three league titles as well as the FA Cup in 1949, he played for England, earning 12 caps. He became England's first substitute in an international on 18 May 1950, scoring against Belgium at Heysel Stadium in a 4–1 win, he played in the 1950 FIFA World Cup and the 1954 FIFA World Cup. He scored 6 goals, including in the 1954 World Cup against Switzerland. During wartime, he served as a soldier in the Army from 1942 onward, based at Farnborough and Barnard Castle.
After retiring from football, he ran a sports shop in Wolverhampton until shortly before his death. Notes: * includes 1 additional game in the Charity ShieldMullen appeared in wartime games, scoring goals Wolverhampton Wanderers First Division champions: 1953–54, 1957–58, 1958–59 Runners-up:1938–39, 1949–50, 1954–55 FA Cup winners: 1949 Official Wolves profile Wolves Heroes
Scottish Voice was a Scottish centre-right political party, launched in February 2007 by Archie Stirling, a wealthy businessman and landowner. The party headquarters were at Craigarnhall, by the town of Bridge of Allan, in the historical parish of Lecropt. Although Stirling is a Unionist, in a statement he said "The position of Scotland within the union is not central to this movement." Many of the new party's supporters were in the Scottish Conservatives, but have found themselves in disagreement with it after its massive decline in Scottish politics in the 1980s and 1990s. At the beginning of April The Scotsman website reported an opinion poll which suggested 21 per cent of voters could cast their regional vote for Scottish Voice. If this support had held until the Scottish Parliament election in May they could have secured a regional list seat. Other news suggested that the Scottish Voice campaign was failing despite importing election agents from Canada to support it. Polling information published on the eve of the election by The Scotsman suggested there was less support for Scottish Voice than the earlier quoted opinion poll.
No minor parties, other than the Scottish Green Party were returned in the election, Scottish Voice failed to win any seats. Scottish Voice received a total of 8,782 votes across the whole of Scotland and this resulted in no Scottish Voice MSPs being elected; the Scotsman reported on 31 August 2007 that figures published by the Electoral Commission revealed Scottish Voice spent £184,920 on its campaign for the Scottish elections that year. This is equivalent of £21.06 for every vote. This made it the most expensive party per vote generated. In April 2012, Stirling announced. Official website Party details from the Electoral Commission website
Myosin light-chain phosphatase, more called myosin phosphatase, is an enzyme that dephosphorylates the regulatory light chain of myosin II. This dephosphorylation reaction occurs in smooth muscle tissue and initiates the relaxation process of the muscle cells. Thus, myosin phosphatase undoes the muscle contraction process initiated by myosin light-chain kinase; the enzyme is composed of three subunits: the catalytic region, the myosin binding subunit, a third subunit of unknown function. The catalytic region uses two manganese ions as catalysts to dephosphorylate the light-chains on myosin, which causes a conformational change in the myosin and relaxes the muscle; the enzyme is conserved and is found in all organisms’ smooth muscle tissue. While it is known that myosin phosphatase is regulated by rho-associated protein kinases, there is current debate about whether other molecules, such as arachidonic acid and cAMP regulate the enzyme. Smooth muscle tissue is made of actin and myosin, two proteins that interact together to produce muscle contraction and relaxation.
Myosin II known as conventional myosin, has two heavy chains that consist of the head and tail domains and four light chains that bind to the heavy chains in the “neck” region. When the muscle needs to contract, calcium ions flow into the cytosol from the sarcoplasmic reticulum, where they activate calmodulin, which in turn activates myosin light-chain kinase. MLC kinase phosphorylates the myosin light chain at the Ser-19 residue; this phosphorylation causes a conformational change in the myosin, activating crossbridge cycling and causing the muscle to contract. Because myosin undergoes a conformational change, the muscle will stay contracted if calcium and activated MLC kinase concentrations are brought to normal levels; the conformational change must be undone to relax the muscle. When myosin phosphatase binds to myosin, it removes the phosphate group. Without the group, the myosin reverts to its original conformation, in which it cannot interact with the actin and hold the muscle tense, so the muscle relaxes.
The muscle will remain in this relaxed position until myosin is phosphorylated by MLC kinase and undergoes a conformational change. Myosin phosphatase is made of three subunits; the catalytic subunit, PP1, is one of the more important Ser/Thr phosphatases in eukaryotic cells, as it plays a role in glycogen metabolism, intracellular transport, protein synthesis, cell division as well as smooth muscle contraction. Because it is so important to basic cellular functions, because there are far fewer protein phosphatases than kinases in cells, PP1’s structure and function is conserved. PP1 works by using two manganese ions as catalysts for the dephosphorylation. Surrounding these ions is a Y-shaped cleft with three grooves: a hydrophobic, an acidic, a C-terminal groove; when PP1 is not bonded to any other subunit, it is not specific. However, when it bonds to the second subunit of myosin phosphatase, MYPT1, this catalytic cleft changes configuration; this results in a dramatic increase in myosin specificity.
Thus, it is clear that MYPT1 has great regulatory power over PP1 and myosin phosphatase without the presence of other activators or inhibitors. The third subunit, M20, is the most mysterious subunit. Little is known about M20, except that it is not necessary for catalysis, as removing the subunit does not affect turnover or selectivity. While some believe it could have regulatory function, nothing has been determined yet; the mechanism of removing the phosphate from Ser-19 is similar to other dephosphorylation reactions in the cell, such as the activation of glycogen synthase. Myosin's regulatory subunit MLC20 binds to both the hydrophobic and acid grooves of PP1 and MYPT1, the regulatory site on myosin phosphatase. Once in the proper configuration, both the phyosphorylated serine and a free water molecule are stabilized by the hydrogen-bonding residues in the active site, as well as the positively charged ions. His-125 donates a proton to Ser-19 MLC20), the water molecule attacks the phosphorus atom.
After shuffling protons to stabilize, the phosphate and alcohol are formed, both leave the active site. The regulatory pathways of MLC kinase have been well-established, but until the late 1980s, it was assumed that myosin phosphatase was not regulated, contraction/relaxation was dependent on MLC kinase activity. However, since the 1980s, the inhibiting effect of rho-associated protein kinase has been discovered and investigated. RhoA GTP activates Rho-kinase, which phosphorylates the MYPT1 at two major inhibitory sites, Thr-696 and Thr-866; this demonstrates the value of the MYPT1, not only to increase reaction rate and specificity, but to slow down the reaction. However, when telokin is added, it undoes the effect of Rho-kinase though it does not dephosphorylate MYPT1. One other proposed regulatory strategy involves arachidonic acid; when arachidonic acid is added to tensed muscle tissue, the acid decreases the rate of dephosphorylation of myosin. However, it is unclear. Two competing theories are that either arachidonic acid acts as a co-messenger in the rho-kinase casca
Coronach is a community in southern Saskatchewan, Canada near the Canada–US border. It was founded in 1926 by the Canadian Pacific Railway and named after Coronach, the horse who had just won The Derby in England that year. Coronach was incorporated in 1928. After its incorporation in 1928 the town's population teetered in and around 300, until about 1974 when the town discovered that they were to receive the Poplar River Power Project; this project brought many new citizens to the town to help with the building and operation of the Power Plant. The Poplar River Power Plant can be seen from a distance with the large smoke stack extending above the town. With the Poplar River Power Project came the development of the Coronach Coal Mine, which provides the coal/fuel to the Power Plant; the Coal mine has had a variety of owners. According to the 2016 Census Coronach has a population of 643 people, this is down from the 2011 census count of 711; the median age in Coronach is 43.0 years. A variety of restaurants, places to stay- Restaurants - Rustic Tavern, Deb's Country Kitchen, RC's Chinese, Coronach Hotel and The Nook Bakery & Coffee Shop - Accommodations - Country Boy Motel, Coronach Hotel, Country Flavour B & B, Coronach Bunkhouse - Camping - Poolside Park Campground, Poplar River Community Park, East Side Campground Coronach Sportsplex Fully equipped campsites Four baseball diamonds Coronach Golf Club with a 9-hole, 3000 yard grass greens course Bowling alley Coronach Medical Center Coronach Museum - was established in 1987 to tell the story of the founding and development of the Coronach district from the year 1900.
There is a hospital room, a schoolroom, communication room, parlour, town office, store, toy room, church and textiles, bathroom to display artifacts that shaped our history K-12 school and Daycare An array of different businesses, services The town is a part owner of the Fife Lake Railway. Scobey–Coronach Border Crossing History of Coronach Map of Coronach at Statcan