Milford High School is a college preparatory, public high school in Milford, Ohio, United States. It is the only high school in the Milford Exempted Village School District (MEVSD), the largest building of the district's eight school buildings, and a larger high school in Clermont County, Ohio. The high school and the Milford Exempted Village School District serve the City of Milford and parts of Miami Township and Union Township. Milford is the westernmost high school in Appalachian Ohio.

Milford is a city in Clermont and Hamilton counties in the U.S. state of Ohio. Milford is the westernmost city in Appalachian Ohio, and located along the Little Miami River and its East Fork in the southwestern part of the state, it is a part of the Cincinnati metropolitan area. The population was 6,582 at the 2020 census.