Milton is a home rule-class city along the south bank of the Ohio River in Trimble County, Kentucky, United States. The population was 597 at the time of the 2020 census, making it the largest city in Trimble County. The Milton-Madison Bridge connects it to Madison, Indiana, and is the only road link between the two states for 40 miles (64 km) in either direction.

Trimble County is a county located in the north central part of the U.S. state of Kentucky. Its county seat is Bedford. The county was founded in 1837 and is named for Robert Trimble. Trimble is no longer a prohibition or dry county. Trimble County is part of the Louisville/Jefferson County, KY–IN Metropolitan Statistical Area.