The Milwaukee School of Engineering (MSOE) is a private university in Milwaukee, Wisconsin. The 22-acre (8.9 ha) campus is in the East Town neighborhood of downtown Milwaukee. In the fall of 2022, it enrolled 2,575 undergraduate and 154 graduate students. As of fall 2018, the university had a total of 138 full-faculty, more than 33% of which are women. Through eight academic departments, the university offers 16 bachelor's degree programs, 10 of which are in engineering. The university also offers nine master's degrees.

Milwaukee is the most populous city in the U.S. state of Wisconsin and the county seat of Milwaukee County. With a population of 577,222 at the 2020 census, Milwaukee is the 31st-most populous city in the United States, and the fifth-most populous city in the Midwest. It is the central city of the Milwaukee metropolitan area, the 40th-most populous metro area in the U.S. Milwaukee is categorized as a "Gamma minus" city by the Globalization and World Cities Research Network, with a regional GDP of over $102 billion in 2020.