Minami-Ōtsuka Station is a passenger railway station located in the city of Kawagoe, Saitama, Japan, operated by the private railway operator Seibu Railway.

Kawagoe is a city in Saitama Prefecture, Japan. As of 1 February 2021, the city had an estimated population of 353,214 in 162,210 households and a population density of 3200 persons per km2. The total area of the city is 109.13 square kilometres (42.14 sq mi). The city is known locally as "Little Edo" after the old name for Tokyo, due to its many historic buildings.