Mindanao Avenue is an eight-to-ten lane divided avenue connecting EDSA and NLEX and is a part of Circumferential Road 5 (C-5) in Metro Manila, Philippines. It is one of the three parallel roads that connects Tandang Sora and Congressional Avenues ; that is why it was named after the southernmost mainland of the Philippines, Mindanao. It used to be a 2-kilometer (1.2 mi) highway connecting North Avenue and Congressional Avenue, but as a part of the C-5 projects, Mindanao Avenue was extended to EDSA in the south and to Quirino Highway to the north. The new roads opened in 2000.

The North Luzon Expressway (NLEX), signed as E1 of the Philippine expressway network, partially as N160 of the Philippine highway network, and partially as R-8 of the Metro Manila arterial road network, is a controlled-access highway that connects Metro Manila to the provinces of the Central Luzon region in the Philippines. The expressway, which includes the main segment and its various spurs, has a total length of 101.8 kilometers (63.3 mi) and travels from its northern terminus at Santa Ines Interchange to its southern terminus in Balintawak Interchange, which is adjacent to its connection to Skyway, an elevated toll road that connects the NLEX to its counterpart in the south, the South Luzon Expressway. The segment of the expressway between Santa Rita Exit in Guiguinto and the Balintawak Interchange in Quezon City is part of Asian Highway 26 of the Asian highway network. Despite that the name stating the word "North Luzon", the expressway only ends at Santa Ines Exit at Mabalacat, Pampanga which is located in Central Luzon.